Yohimbine HCL is a potent vasodilator, which means that it increases blood flow to the extremities, which is what is thought to be responsible for Yohimbine’s effect on increasing sex drive. It has also been shown to increase fatty acid mobilization, which in turn may help individuals lose more body fat and stubborn fat in problem areas.

Yohimbine has been studied as a potential treatment for erectile dysfunction but there is insufficient evidence to rate its effectiveness.

Yohimbine blocks the pre- and post-synaptic α2 receptors. Blockade of post-synaptic α2 receptors causes only minor corpus cavernosum smooth muscle relaxation, due to the fact that the majority of adrenoceptors in the corpus cavernosum are of the α1 type. Blockade of pre-synaptic α2 receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system — thus in the corpus cavernosum — such as nitric oxide and norepinephrine. Whereas nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, norepinephrine is the major vasoconstrictor through stimulation of α1 receptors on the corpus cavernosum smooth muscle. Under physiologic conditions, however, nitric oxide attenuates norepinephrine vasoconstriction.

Toxicity
Depending on dosage, Yohimbine can either increase or decrease systemic blood pressure (through vasoconstriction or vasodilation, respectively). Because Yohimbine has highest affinity for the α2 receptor, small doses can increase blood pressure by causing a relatively selective α2 blockade. Yohimbine also, however, interacts with α1 receptors, albeit with lower affinity; therefore, at higher doses an α1 blockade can occur and overwhelm the effects of the α2 blockade, leading to a potentially dangerous drop in blood pressure. Higher doses of oral Yohimbine may create numerous side effects, such as rapid heart rate, over-stimulation, anomalous blood pressure, cold sweating, and insomnia.

Serving Size: 1-2 5mg capsules per day.